What is eribulin made from?
Eribulin is a laboratory-made form of halichondrin B, a substance derived from a sea sponge. Similar to some other chemotherapy drugs, it targets the protein tubulin in cells, although it binds to tubulin in a different way, interfering with cancer cell division and growth.
How does eribulin mesylate work?
Eribulin mesylate works by disrupting the microtubular network in cells that is essential for cell division. Eribulin mesylate inhibits the growth of microtubules into the “mitotic spindle,” which is the apparatus that is responsible for physically separating parts of the cell as it divides.
Is eribulin a taxane?
Eribulin is a non-taxane microtubule inhibitor that is a structurally modified synthetic analog of halichondrin B (Jordan et al.
Is eribulin a mesylate chemotherapy?
Eribulin mesylate is a chemotherapeutic medicine approved to treat metastatic breast cancer, an advanced form of breast cancer that has spread to other parts of the body.
How long can you stay on eribulin?
Eribulin was effective against the lung metastases for more than 1 year.
What is another name for eribulin?
Eribulin is the generic name for the trade name drug Halaven. In some cases, health care professionals may use the trade name Halaven when referring to the generic drug name eribulin.
When is eribulin used?
Eribulin injection is used to treat breast cancer that has spread to other parts of the body and that has already been treated with certain other chemotherapy medications. Eribulin is in a class of anticancer medications called microtubule dynamics inhibitors. It works by stopping the growth and spread of cancer cells.
What class of drug is eribulin?
Eribulin is in a class of anticancer medications called microtubule dynamics inhibitors. It works by stopping the growth and spread of cancer cells.
How long is eribulin effective?
How effective is eribulin?
Remarkably, relevant CNS efficacy was observed with eribulin: 20% of patients obtained partial response and 25% SD. Treatment was generally well tolerated and manageable, with 29% grade 3 and 10.9% grade 4 toxicities. Median PFS and OS were 4.1 months (CI95% 3.2–4.9) and 11.1 months (CI95% 9.5–14.7), respectively.
What drug class is eribulin?
How is the synthesis of eribulin mesylate carried out?
The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon–carbon bond and macrocyclic ring closure through an intramolecular Nozaki–Hiyama–Kishi reaction. The synthesis of the C27–C35 tetrahydrofuran fragment.
When was Eribulin mesylate approved for breast cancer?
Eribulin mesylate was approved by the U.S. Food and Drug Administration on November 15, 2010, to treat patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline – and taxane -based chemotherapies. [1]
Which is domain of eribulin inhibits mitotic spindle assembly?
Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.