What is HIV genotype testing?
Genotypic resistance testing examines the genetic structure (genotype) of a patient’s HIV. A blood sample is taken from the patient, and the HIV is analyzed for the presence of specific genetic mutations that are known to cause resistance to specific drugs.
How does HIV become resistant to AZT?
Human immunodeficiency virus (HIV-1) develops resistance to 3′-azido-2′,3′-deoxythymidine (AZT, zidovudine) by acquiring mutations in reverse transcriptase that enhance the ATP-mediated excision of AZT monophosphate from the 3′ end of the primer.
Which is an appropriate test to perform in cases where a drug resistant HIV strain is suspected?
Drug-resistance testing is recommended (AII). A genotypic assay is generally preferred (AIII). Treatment should not be delayed while awaiting results of resistance testing (AIII). Drug-resistance testing can determine whether drug-resistant virus was transmitted.
How do you know if you’re HIV resistant?
1. You’re experiencing flu-like symptoms. Most patients experience flu-like symptoms when they are first infected with HIV, including: fevers, body aches, night sweats, sore throat, and rash. These same symptoms can happen while on HIV medications if your virus “breaks through” due to HIV drug resistance.
What is a genotype test?
Genotyping is the process of determining the DNA sequence, called a genotype, at specific positions within the genome of an individual. Sequence variations can be used as markers in linkage and association studies to determine genes relevant to specific traits or disease.
What are 2 cons of genetic testing?
Some disadvantages, or risks, that come from genetic testing can include:
- Testing may increase your stress and anxiety.
- Results in some cases may return inconclusive or uncertain.
- Negative impact on family and personal relationships.
- You might not be eligible if you do not fit certain criteria required for testing.