What bioreactors are used in tissue engineering application?
2. Common Types of Bioreactors
Authors | Cell source | Type of bioreactor |
---|---|---|
Xu et al. [23] | Chondrocytes | Spinner flasks |
Yoon et al. [24] | hADSCs | Spinner flasks |
Zhu et al. [25] | hADSCs | Rotating wall vessels |
Nordberg et al. [26] | RCS | Rotating wall vessels |
What is bioreactor in tissue engineering?
Bioreactors are defined as a device used to develop biological processes by closely monitoring controlled environments [1]. They are used within the field of tissue engineering as a method for studying and mimicking traditional in vitro studies in an in vivo environment for the growth of tissue substitutes [2].
What are the main features needed for a bioreactor intended for functional tissue engineering?
In essence, the bioreactor needs to provide the appropriate physical stimulation to cells, continuous supply of nutrients (e.g. glucose, amino acids), biochemical factors and oxygen, diffusion of chemical species to the construct interior, as well as continuous removal of by-products of cellular metabolism (e.g. lactic …
Why are bioreactors used?
Bioreactor systems are a vital component in the process of 3D tissue engineering and the formation of tissue constructs. Bioreactors are used to provide a tissue-specific physiological in vitro environment during tissue maturation. Based on the bioreactor technology, various tissue systems can be incubated in vitro.
What is the principle of bioreactor?
In bioreactors, the principle is the same; CO2 is introduced to the culture from a compressed gas cylinder. In bioreactors, the medium pH is continuously measured using a pH sensor and CO2 is added as needed.
How is tissue engineering done?
It involves forming a 3D functional tissue to help repair, replace, and regenerate a tissue or an organ in the body. To do this, cells and biomolecules are combined with scaffolds. When these are constructed together, new tissue is engineered to replicate the old tissue’s state when it wasn’t damaged or diseased.
What are the characteristics of bioreactors?
Inhomogeneous system, time instability, and space instability are three main characteristics of anaerobic bioreactor (AB).
What type of bioreactor mode is more efficient?
In general, the airlift bioreactors are more efficient than bubble columns, particularly for more denser suspensions of microorganisms. This is mainly because in these bioreactors, the mixing of the contents is better compared to bubble columns.