What are the types of tuberculosis TB drug resistance?

What are the types of tuberculosis TB drug resistance?

What are the main types of drug resistant TB? There are two main types, MDR TB and XDR TB. MDR TB is the name given to TB when the bacteria that are causing it are resistant to at least isoniazid and rifampicin, two of the most effective TB drugs.

What is the most significant anti tuberculosis drug?

Isoniazid (INH) is one of the most effective and specific antituberculosis drugs, which has been a key to treatment since its introduction in 1952 [5].

Is TB resistant to rifampicin?

Rifampicin, as the most effective first-line antituberculosis drug, also develops resistance due to the mutation on Mycobacterium tuberculosis (Mtb) RNA polymerase.

How do you rechallenge anti TB?

Start streptomycin, moxifloxacin and ethambutol. Repeat ALT and bilirubin after 2-3 days. Rechallenge TB drugs when ALT< 100 IU/l •and bilirubin normal.

What are the symptoms of drug resistant TB?

What are the symptoms of XDR TB? The general symptoms of TB disease include feelings of sickness or weakness, weight loss, fever, and night sweats. The symptoms of TB disease of the lungs may also include coughing, chest pain, and coughing up blood.

What drugs is TB resistant to?

Extensively drug-resistant TB (XDR TB) is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin). Treating and curing drug-resistant TB is complicated.

Is TB resistant to antibiotics?

Like other bacterial pathogens, Mycobacterium tuberculosis—the bacterium that causes TB—has developed resistance to antibiotic treatments over time via chromosomal mutations that protect the organism against the action of the drugs.

For what purpose is tuberculosis treatment monitored?

All patients should be monitored to assess their response to therapy (Standard 10 of the ISTC (1)). Regular monitoring of patients also facilitates treatment completion and allows the identification and management of adverse drug reactions.

Is drug resistant tuberculosis curable?

Only about half the people with MDR-TB around the world are successfully cured. TB treatment is lengthy and burdensome to patients and treatment providers alike. MDR-TB treatment can consist of more than 14,000 pills, plus daily injections for six months.