Can gastric bypass cause schizophrenia?
Psychotic manifestations after gastric bypass surgery have been reported by many groups (12–15). Others have reported similar psychotic symptoms in patients after gastrectomy (16), a hunger strike (17), and a crash diet for weight loss (18).
Does gastric bypass change your personality?
Diet and Personality Change after Bariatric Surgery These restrictions typically change serotonin levels as well as neurotransmitter activity in the brain. Sometimes depression and anxiety manifest as less positive personality changes after bariatric surgery.
Why did my gastric bypass fail?
In fact, 15% of gastric bypass will fail because of inadequate weight loss or regain from excessive ingestion of high-fat junk foods. Patients can also develop dumping syndrome with the ingestion of high calorie liquids and sweets, also known as soft calories.
Are there any pharmacokinetic studies on gastric bypass?
Despite the frequency of psychotropic drug use by bariatric surgical patients, pharmacokinetic studies are rare. In a study of five Roux-en-Y gastric bypass patients treated with sertraline for major depression, the patients had a lower mean AUC compared with non-surgical comparison subjects after receiving a dose of 100 mg sertraline ( 19 ).
How are psychiatric medications affected by gastric bypass?
An in vitro drug dissolution model approximating the Roux-en-Y gastric bypass environment demonstrated that 10 of 22 psychiatric medications had significantly less dissolution compared with the control environment ( 27 ).
Is the Sri bioavailability reduced after gastric bypass?
Having observed that patients treated with SRIs frequently relapse after Roux-en-Y gastric bypass surgery, the authors sought to assess whether SRI bioavailability is reduced postoperatively. Twelve gastric bypass candidates treated with an SRI for primary mood or anxiety disorders were studied prospectively.
What happens to the AUC after gastric bypass?
Normalization of the AUC was associated with improvement in symptom scores. Patients taking SRIs in this study were at risk for reduced drug bioavailability 1 month after Roux-en-Y gastric bypass. The authors recommend close psychiatric monitoring after surgery. Obesity has reached epidemic status in the United States.