How can you tell the difference between a giant cell tumor and an aneurysmal bone cyst?

How can you tell the difference between a giant cell tumor and an aneurysmal bone cyst?

Septation was seen in both tumors. Typical of ABC was a sharp and trabeculated margin, whereas GCT had an ill-defined edge with normal cancellous bone (P = 0.007). The growth of ABCs often expanded the cortex, while GCTs eroded, thinned, and broke the cortical bone (P = 0.001).

What is giant cell tumor?

A giant cell tumor is a rare, aggressive, noncancer tumor. It often grows near a joint at the end of the bone. Most occur in the long bones of the legs and arms. They most often occur in young adults when skeletal bone growth is complete. Symptoms may include joint pain, swelling, and limited movement.

What are the radiographic manifestations of giant cell tumor?

The most important radiographic findings of giant cell tumor are the location of the tumor, its lytic nature, and the lack of a host response. Typically, giant cell tumors are expansile, osteolytic, radiolucent lesions without sclerotic margins and usually without a periosteal reaction.

What is the most common site for giant cell tumors?

Key points about giant cell tumors Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.

How rare is an aneurysmal bone cyst?

An aneurysmal bone cyst (ABC) is a highly destructive benign bone tumor, occurring in less than 1 in 100,000 people per year. The term “aneurysmal” refers to the explosive, expansile nature of the bone containing the aneurysmal bone cyst, similar to the enlargement seen with blood vessel or heart aneurysms.

Do bone cysts grow?

These cysts are made up of multiple blood-filled sacs that are packed together. These cysts usually occur near the inside edges of the long bones (upper arm and thigh bones), but almost any bone may be affected. The cysts tend to grow slowly.

What are giant cells that destroy bone?

Osteoclasts Resorb Bone Osteoclasts are giant cells containing between 10 and 20 nuclei. They closely attach to the bone matrix by binding its surface integrins to a bone protein called vitronectin.

Can giant cell tumor recur?

Clinically, GCT presents as a benign but often aggressive lesion with a tendency toward local recurrence. Depending on the type of treatment and the local presentation of the tumor, recurrence rates range from 0% to 65% (Table 1) [1, 3, 5, 6, 15, 20, 25, 26, 29, 31, 37, 38, 40, 43, 50].