How fast does smoldering myeloma progress?
If two of these are present, a patient has intermediate risk smoldering myeloma with an average between 3-5 years to progression to symptomatic myeloma. The intermediate risk has an average time of between 3 and 5 years to progression.
Does myeloma cause dementia?
Degree of dementia and prognosis should be serious considerations in determining treatment options for myeloma. Complications such as infection, hypercalcemia, and renal insufficiency are likely to cause delirium in a patient with underlying dementia.
Does smoldering myeloma always progress?
The good news is that it does not always progress and we can actually divide people up into those who are at low risk, intermediate risk, or high risk. If you have low risk smoldering myeloma, that’s almost the same risk of progression as what we call MGUS or monoclonal gammopathy of undetermined significance.
How long can you live with smoldering multiple myeloma?
Among patients with progression of smoldering multiple myeloma, 97% had progression to active multiple myeloma. Rates of death owing to other diseases, including cardiovascular and cerebrovascular disease and non–plasma-cell cancers, were 18% at 5 years, 26% at 10 years, 30% at 15 years, and 35% at 20 years.
How does smoldering myeloma progress?
Smoldering myeloma is a precancerous condition that alters certain proteins in blood and/or increases plasma cells in bone marrow, but it does not cause symptoms of disease. About half of those diagnosed with the condition, however, will develop multiple myeloma within 5 years.
Does myeloma cause memory loss?
Mind and memory problems are common in myeloma and can be extremely frustrating. Our team of Myeloma Information Specialists often get calls and emails from patients who are experiencing problems such as mental fogginess and difficulty remembering words.
Is there treatment for smoldering myeloma?
Because there are no approved treatments for smoldering myeloma, doctors have long adopted a “watch and wait” approach, closely monitoring individuals for evidence of progression to active (symptomatic) multiple myeloma, such as damage to certain organs.
Does smoldering myeloma cause fatigue?
While most individuals with SMM do not have any symptoms at first, they may develop symptoms if the condition progresses to multiple myeloma, including: bone pain. brittle bones. fatigue (lack of energy) and weakness.
What is the prognosis for smoldering multiple myeloma?
Among patients with progression of smoldering multiple myeloma, 97% had progression to active multiple myeloma. Rates of death owing to other diseases, including cardiovascular and cerebrovascular disease and non–plasma-cell cancers, were 18% at 5 years, 26% at 10 years, 30% at 15 years, and 35% at 20 years.
What is the risk of progression of multiple myeloma?
We found that the overall risk of progression among patients with smoldering multiple myeloma was approximately 10% per year in the first 5 years and 3% per year in the next 5 years with a decrease to 1% per year thereafter. No such time-dependent change in risk occurs with MGUS.
Why is smoldering myeloma referred to as SMM?
The reason the disorder is referred to as “smoldering” is that it often worsens slowly over time. Although people with SMM are at risk for developing multiple myeloma, the progression of the disease does not always occur.
What are the new IMWG criteria for smoldering myeloma?
The Spanish Myeloma Group ran the first study testing the use of lenalidomide and dexamethasone vs. observation which showed greater time to progression in the len/dex arm. Similarly, the Eastern Cooperative Oncology Group (ECOG) ran a lenalidomide only study which also showed significant benefit vs. observation.