Is DPPC a phospholipid?
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid (and a lecithin) consisting of two C16 palmitic acid groups attached to a phosphatidylcholine head-group.
Where is DPPC synthesized?
The synthesis of DPPC, similar to that of other phospholipids, has been thoroughly studied and is reviewed. The building blocks, glycerol, palmitic acid, choline and phosphate, are generally produced in the lung itself, but choline is generously supplied with the bloodstream.
How does DPPC work?
DPPC is generally accepted as being the lipid responsible for generating a near-zero surface tension at the interface during compression . The two saturated acyl chains enable the lipid to form a tightly packed monolayer which can generate these low surface tension values without collapsing.
Is phospholipid a surfactant?
Surfactant is a macromolecular complex largely composed of phospholipids (80–85%), mainly phosphatidylcholine of which dipalmitoylphosphatidylcholine is the major surface-active component; neutral lipids (5–10%); and surfactant-specific proteins A–D (5–10%).
Is lecithin a surfactant?
Lecithins have emulsification and lubricant properties, and are a surfactant. They can be completely metabolized (see inositol) by humans, so are well tolerated by humans and nontoxic when ingested; some other emulsifiers can only be excreted via the kidneys.
What are the benefits of phospholipids?
Phospholipids are essential to health. They play a number of roles in the body, acting as a major component of cellular membranes and facilitating the absorption and transportation of important omega-3 fats throughout the body.
What is the full form of DPPC?
DPPC – Disaster Prevention and Preparedness Commission.
What causes lack of surfactant?
Surfactant dysfunction is caused by mutations in one of several genes, including SFTPB, SFTPC, and ABCA3. Each of these genes is involved in the production of surfactant. The production and release of surfactant is a complex process.
What kind of Medicine is dipalmitoylphosphatidylcholine used for?
Dipalmitoylphosphatidylcholine (DPPC) is routinely used to formulate some medicines used for treatment of respiratory distress syndrome (RDS) in newborns. Current synthetic surfactants are combinations of DPPC along with other phospholipids, neutral lipids and lipoproteins.
How is dipalmitoylphosphatidylcholine related to pulmonary surfactants?
?) Dipalmitoylphosphatidylcholine ( DPPC) is a phospholipid (and a lecithin) consisting of two palmitic acids attached to a phosphatidylcholine head-group. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing.
Which is a component of the phospholipid dipalmitoylphosphatidylcholine head group?
Dipalmitoylphosphatidylcholine ( DPPC) is a phospholipid (and a lecithin) consisting of two palmitic acids attached to a phosphatidylcholine head-group. It is the main constituent of pulmonary surfactants, which reduces the work of breathing and prevents alveolar collapse during breathing.
What is the molecular formula of 1, 2-dipalmitoylphosphatidylcholine?
1,2-Dipalmitoylphosphatidylcholine PubChem CID 6138 Structure Find Similar Structures Molecular Formula C40H80NO8P Synonyms 2644-64-6 DL-Dipalmitoylphosphatidylchol Molecular Weight 734.0