Is Soliris removed by dialysis?
Because eculizumab has an estimated molecular weight of 148,000 Da, we expected minimal removal of the drug by hemodialysis.
What disease does Soliris treat?
SOLIRIS® is used to treat adults with neuromyelitis optica spectrum disorder (NMOSD) who are anti-aquaporin-4 (AQP4) antibody-positive, as well as have paroxysmal nocturnal hemoglobinuria (PNH), hemolytic uremic syndrome (aHUS), and myasthenia gravis.
Can you recover from aHUS?
Observational data show improved recovery of renal function (decreased serum creatinine levels) in five patients who received eculizumab therapy within 28 days of the start of the last aHUS event when compared to 7 patients who received treatment after ≥28 days [9].
What is Soliris given for?
This medication is used to treat a certain blood disorder (paroxysmal nocturnal hemoglobinuria). This disorder can cause a decrease in red blood cells (anemia).
How much is Soliris cost?
Priced at $678,392 per year, Soliris is used to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome — blood disorders that result in the destruction of red blood cells. The dosing regimen for Soliris can differ depending on the age of the patient and the condition being treated.
Who owns Soliris?
Alexion Pharmaceuticals
| Type | Subsidiary |
|---|---|
| Headquarters | Boston, Massachusetts |
| Key people | Leonard Bell (Chairman) Ludwig N. Hantson (CEO) |
| Products | Eculizumab (Soliris) Ravulizumab (Ultomiris) Asfotase alfa (Strensiq) Sebelipase alfa (Kanuma) Andexanet alfa (Andexxa) |
| Revenue | US$6.069 billion (2020) |
Is Solaris a chemotherapy drug?
Eculizumab is the generic name for the trade chemotherapy drug Soliris. In some cases, health care professionals may use the trade name Soliris when referring to the generic drug name eculizumab.
Can Soliris be administered at home?
Soliris is a treatment that is given by intravenous (IV) infusion. Some people visit an infusion center to receive Soliris while others prefer to have a visiting nurse administer their infusion at home. The location in which you receive your infusion can depend on your insurance and where you live.
Is aHUS serious?
Complications of aHUS are serious. aHUS causes the body to develop too many blood clots, which causes your blood to flow too slowly to important organs.
How much does eculizumab cost?
Table 8CADTH Cost Comparison Table for Prescription Drugs Indicated for NMOSD Patients
| Treatment | Strength | Price, $ |
|---|---|---|
| Eculizumab (Soliris) | 10 mg/mL | 6,742.0000 |
How expensive is Soliris?
How long can you take Soliris?
Interrupting your treatment could cause sudden and serious effects on your red blood cells. Eculizumab can effect your body for up to 3 months. You may need medical tests for 8 to 12 weeks if you stop using this medicine.