What deficiency causes Keshan disease?
Keshan disease (KD) is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. It is named for the northeastern Chinese county Keshan, where the disease prevalence is high because of selenium-deficient soil.
Which viral infection in combination to selenium deficiency causes Keshan disease?
Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of Coxsackievirus, named after Keshan County of Heilongjiang province, Northeast China, where symptoms were first noted.
What is endemic cardiomyopathy?
Abstract. Keshan disease is an endemic cardiomyopathy in China. Morphologically, the condition is characterized by multifocal necrosis and replacement fibrosis of the myocardium, resulting in acute or chronic heart failure.
What are the symptoms of Keshan disease?
The main clinical features of Keshan disease are cardiac insufficiency and enlargement, electrocardiographic changes, and fibrosis. In 1979 Keshan disease was reported to be responsive to supplementation with sodium selenite and was initially thought to be a simple selenium deficiency.
Is pellagra genetic?
Hartnup disease is a genetic disorder that reduces tryptophan absorption, leading to pellagra. Alterations in protein metabolism may also produce pellagra-like symptoms.
What is the result of selenium deficiency?
Selenium deficiency has been found to have a role in human growth and reproduction as well. Moderate deficiency plays a role in myodegenerative diseases, such as muscle weakness. Low selenium state has been associated with depressed mood, anxiety, and confusion.
What is Keshan’s disease?
Keshan disease (KD) as an endemic, highly lethal cardiomyopathy, first reported in northeast China’s Keshan County in 1935. The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia.
What foods are high in selenium?
Selenium and Healthful Diets
- Many whole grains and dairy products, including milk and yogurt, are good sources of selenium.
- Pork, beef, turkey, chicken, fish, shellfish, and eggs contain high amounts of selenium.