What is agranulocytosis aplastic anemia?
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing a neutropenia in the circulating blood.
Is agranulocytosis the same as aplastic anemia?
Agranulocytosis and aplastic anemia are both rare, life-threatening blood dyscrasias. Agranulocytosis is mainly caused by medicines, whereas the etiology of aplastic anemia is largely unexplained.
What are symptoms of agranulocytosis?
Having very low levels of granulocytes in the blood can lead to serious or life-threatening infections. Signs and symptoms of agranulocytosis include fever, chills, weakness, sore throat, sores in the mouth or throat, bleeding gums, bone pain, low blood pressure, fast heartbeat, and trouble breathing.
How does agranulocytosis affect your body?
Agranulocytosis can cause severe problems in people who have other health conditions, such as kidney disease, heart disease or breathing problems. Untreated, agranulocytosis leads to severe infection and death. The risk of infection increases the longer the neutrophil count remains dangerously low.
Which of the following medications may cause a patient to experience agranulocytosis as an adverse effect?
Drugs that can cause agranulocytosis include: antithyroid medications, such as carbimazole and methimazole (Tapazole) anti-inflammatory medications, such as sulfasalazine (Azulfidine), dipyrone (Metamizole), and nonsteroidal anti-inflammatory drugs (NSAIDs) antipsychotics, such as clozapine (Clozaril)
What happens to your blood when you have aplastic anemia?
Aplastic anemia occurs when your bone marrow doesn’t make enough red and white blood cells, and platelets. Having fewer red blood cells causes hemoglobin to drop. Hemoglobin is the part of blood that carries oxygen through your body.
What happens to white blood cells in agranulocytosis?
Agranulocytosis is a life-threatening blood disorder. It happens when the body doesn’t make enough of a type of white blood cells called neutrophils. White blood cells are part of the immune system. They protect the body from infection by fighting off germs that make us sick.
Can a bone marrow transplant cause aplastic anemia?
Radiation and chemotherapy treatments. While these cancer-fighting therapies kill cancer cells, they can also damage healthy cells, including stem cells in bone marrow. Aplastic anemia can be a temporary side effect of these treatments.
Can you get aplastic anemia if you have myelodysplastic syndrome?
Confusion with myelodysplastic syndrome. Aplastic anemia can be mistaken for a condition called myelodysplastic syndrome. In this group of disorders, the bone marrow produces new blood cells, but they’re deformed and underdeveloped.