What is Chondrogenic differentiation?
Chondrogenic Induction. Bone marrow-derived mesenchymal stem cells can be induced to differentiate into chondrocytes under specific culture conditions. Together with these physical culture conditions, a defined culture medium containing TGF-β1 is required to achieve chondrogenic differentiation (18, 19, 78).
Where are mesenchymal bone marrow stem cells derived from?
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into several mesodermal lineages. These cells have been isolated from various tissues, such as adult bone marrow, placenta, and fetal tissues.
What do mesenchymal cells differentiate into?
Mesenchymal stem cells (MSCs), or stromal stem cells, can differentiate into many different types of cells within the body, including: Bone cells, Cartilage, Muscle cells, Neural cells, Skin cells, and Corneal cells.
What is the preferred tissue mesenchymal stem cells are harvested from?
The most common and longest utilized adult source tissues for human MSCs are bone marrow3,6 and the adipose tissue stromal vascular fraction7,8 and these sources form the foundation for most of the data in this field (Fig. 1a).
Are chondrocytes differentiated?
Chondrocyte and osteoblast are two primary cell types in the skeletal systems that are differentiated from common mesenchymal progenitors.
Is Endochondral an ossification?
Endochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone.
What is the difference between mesenchymal and parenchymal?
Parenchyma cells are the most common ground tissues in plants. They have a thin cell wall compared to other cell types. On the other hand, mesenchymal cells are a type of connective tissue cells found during the embryonic development. They are multipotent cells that are able to differentiate into many cell types.
What is the function of mesenchymal cells?
Mesenchymal stem cells (MSCs) are multipotent stem cells found in bone marrow that are important for making and repairing skeletal tissues, such as cartilage, bone and the fat found in bone marrow.
Why does ossification end?
Ossification of long bones proceeds until only a thin strip of cartilage remains at either end; this cartilage, called the epiphyseal plate, persists until the bone reaches its full adult length and is then replaced with bone.