What is CK7 positive in cancer?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
Is CK7 positive in squamous cell carcinoma?
CK7’s expression is low in squamous cell carcinoma of lungs and small cell lung carcinoma. In addition, the expression of CK7 is significantly different (P<0.01) in squamous cell carcinoma, adenocarcinoma of lungs and small cell lung carcinoma, which can facilitate the diagnosis of the three types of lung cancer.
Is embryonal carcinoma cancerous?
Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle.
What is embryonal carcinoma?
Embryonal carcinoma is a germ cell tumor characterized by primitive epithelial cells with marked pleomorphism and various histologic patterns. It may present in pure form but often is part of a mixed germ cell tumor.
Why is embryonal carcinoma called?
Embryonal carcinoma can increase blood levels of a tumor marker protein called alpha-fetoprotein (AFP), as well as human chorionic gonadotropin (HCG). Yolk sac carcinoma: These tumors are so named because their cells look like the yolk sac of an early human embryo.
Is embryonal carcinoma painful?
Conclusion. Embryonal cell carcinoma is one of the most common testicular malignancies. Testicular carcinomas most commonly occur in 20- to 30-year-old men. Some common symptoms of embryonal cell carcinoma include swelling and a painful, palpable mass located on the testis.
Why is it called embryonal carcinoma?
Yolk sac carcinoma: These tumors are so named because their cells look like the yolk sac of an early human embryo. Other names for this cancer include yolk sac tumor, endodermal sinus tumor, infantile embryonal carcinoma, or orchidoblastoma.
Does carcinoma mean malignant?
Carcinoma is a malignancy that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a malignancy that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
What kind of cancer can CK7 be used for?
Squamous cell carcinoma (with exception of cervix, a subset of head and neck squamous cell carcinomas and a subset of cutaneous squamous cell carcinomas, particularly poorly differentiated tumors, which can express focal-to-partial positivity for CK7) ( Head Neck Pathol 2018;12:448, J Cutan Pathol 2010;37:966 )
Is there such a thing as embryonal carcinoma?
Embryonal Carcinoma. Embryonal carcinoma is a rare type of nonseminomatous germ cell tumor occurring in the mediastinum of young males, as either a pure or a mixed form. 47 It is often associated with teratoma (i.e. teratocarcinoma), choriocarcinoma, or seminoma. The serum alpha-fetoprotein level is elevated in almost all cases.
What kind of cells are positive for CK7?
Immunohistochemical studies show the cells to be positive for CK7, CAM5.2 and HER2 while negative for SOX10, p63, CK5/6, CK20 and adipophilin. The morphologic and immunophenotypic findings are consistent with primary Paget disease of the vulva.
Which is more specific CK7 or CD117?
Addition of Claudin-7 and CD117 to CK7 or the “three 7 markers” further increases specificity for chromophobe renal cell carcinoma versus other histologic mimics ( Dis Markers 2019;2019:4708154 )