Where are antigens loaded into MHC class II complexes?

Where are antigens loaded into MHC class II complexes?

endosomes
Antigenic fragments and self-peptides are loaded onto MHC class II molecules in late endosomes or MHC class II containing compartments (MIICs).

How are antigens processed?

Antigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. Both MHC class I and II are required to bind antigen before they are stably expressed on a cell surface.

What cells recognize MHC 2?

MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.

What is an example of an antigen?

Antigen (definition in biology): any of the various substances that when recognized as non-self by the immune system will trigger an immune response. Examples: allergens, blood group antigens, HLA, substances on the surface of foreign cells, toxins.

How is the distribution of MHC class II controlled?

Pathway showing how MHC-II distribution is controlled within Immature Dendritic Cells. One type of MHC class II deficiency, also called bare lymphocyte syndrome, is due to mutations in the genes that code for transcription factors that regulate the expression of the MHC class II genes.

What’s the difference between MHC 1 and 2?

Function MHC I involves in the clearance of endogenous antigens. MHC II involves in the clearance of exogenous antigens. Summary – MHC I vs II. MHC molecules are mainly of two types, Class I and Class II.

What happens when MHC class II molecules are deficient?

Deficient MHC class II molecules are unable to present antigens to T cells and properly activate T cells. T cells are then unable to proliferate, and secrete cytokines which normally participate in the immune response.

How does MHC class II interact with immune cells?

Class II molecules interact mainly with immune cells, like the T helper cell (CD4+). The peptide presented regulates how T cells respond to an infection.