Who are the parents of actor Gene Kelly?
Gene Kelly (I) (1912–1996) Eugene Curran Kelly was born in Pittsburgh, Pennsylvania, the third son of Harriet Catherine (Curran) and James Patrick Joseph Kelly, a phonograph salesman. His father was of Irish descent and his mother was of Irish and German ancestry. Metro-Goldwyn-Mayer was the largest and most powerful studio in Hollywood…
Are there any recessive mutations in the agrin gene?
these observations indicate that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4/MuSK signaling at the NMJ. Five new recessive mutations in the gene encoding agrin are identified in patients with congenital myasthenic syndrome.
What is the gene ID for AGRN agrin?
AGRN agrin [ (human)] Gene ID: 375790, updated on 19-Jan-2017. This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains.
What is the role of agrin in the BBB?
Agrin, a heparan sulfate proteoglycan, is a component of the basal lamina of BBB microvessels, and growing evidence suggests that it may be important for the maintenance of the BBB. acts at the nerve-muscle synapse in the glomerular basal membrane and on T-lymphocytes
Why did Gene Kelly break up with his wife?
She began affairs, informing Kelly that she wanted to see what else the world held for her. Kelly was committed to the marriage, but it didn’t matter. One of Kelly’s biggest hallmarks was the charming grin that effortlessly flashed across his face in each of his film roles.
Who was Gene Kelly’s brother in the time of Your Life?
He and his younger brother Fred Kelly appeared together in a dancing vaudeville act. When Gene got his big break as Harry the hoofer in the dramatic Broadway production of “The Time of Your Life” in 1939, he was eventually replaced by brother Fred, who took it on the road and won a Donaldson award for his efforts.
What was the first movie Gene Kelly was in?
Gene Kelly may have made his film debut opposite Judy Garland, however, when they were cast alongside one another in The Pirate, they found the experience to be decidedly different. Judy hadn’t been fully sold on making the film, which was being directed by her then-husband, from the beginning.