Why is Xenical more expensive than orlistat?
In the same way that Nurofen is the brand name of the drug ibuprofen, Orlistat is the drug, while Xenical is a branded version of the drug. This is why the generic version of the Xenical weight loss drug is marketed as Orlistat. Orlistat’s ‘generic’ status allows it to be sold at a cheaper price than Xenical.
How many times a day do you take orlistat?
Orlistat comes as a capsule and a nonprescription capsule to take by mouth. It is usually taken three times a day with each main meal that contains fat. Take orlistat during a meal or up to 1 hour after a meal. If a meal is missed or does not have fat, you may skip your dose.
When should I take Xenical orlistat?
Orlistat is usually taken 3 times per day with each main meal that contains some fat (no more than 30% of the calories for that meal). You may take the medicine either with your meal or up to 1 hour after eating. If you skip a meal or you eat a meal that does not contain any fat, skip your orlistat dose for that meal.
What happens if you take Orlistat without eating?
If there is no fat in one of your meals, or if you miss a meal, there is no need for you to take a dose of orlistat. Common side-effects include wind, loose stools and back passage (rectal) spotting, particularly at the beginning of treatment.
Is Orlistat stronger than Alli?
Alli (60mg) is an over-the-counter treatment that prevents 1/4 of dietary fat from being digested. It is not as strong as Xenical or orlistat but is the cheapest tablet overall.
How does Xenical work as a lipase inhibitor?
XENICAL (orlistat) is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats. Orlistat is (S)-2-formylamino-4-methyl-pentanoic acid (S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2 oxetanyl] methyl]-dodecyl ester. Its empirical formula is C 29 H 53 NO 5 , and its molecular weight is 495.7.
Is there A P K A in Xenical capsules?
Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat has no p K a within the physiological pH range. XENICAL is available for oral administration in dark-blue, hard-gelatin capsules, with light-blue imprinting.
Where does orlistat work in the small intestine?
Orlistat is a reversible inhibitor of lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases.
What is the half life of orlistat capsules?
The disposition of orlistat appeared to be similar between normal weight and obese subjects. Based on limited data, the half-life of the absorbed orlistat is in the range of 1 to 2 hours. Special Populations