What are organ-specific autoimmune disease?
Organ-specific autoimmune diseases are those where a particular organ or tissue is preferentially targeted by the patient’s immune system. For example, the thyroid gland in patients with Graves disease, the beta cells of the endocrine pancreas in patients with type 1 diabetes, or the skin in patients with vitiligo.
Is Sjogren’s syndrome organ-specific?
Sjögren’s syndrome (SS) in humans is an organ-specific autoimmune disease characterized by lymphocytic infiltration into the salivary and lacrimal glands (Fig. 1), resulting in dry mouth and dry eyes due to deficient secretion of saliva and tears [1], [2].
Which autoimmune disease affects single organ?
Type 1 diabetes and a certain kind of hepatitis are among the autoimmune conditions in which the immune system attacks one organ. Organ-specific autoimmune diseases, as the name suggests, are defined as disorders in which the body’s immune response attacks healthy cells in a specific organ.
What are systemic and organ-specific autoimmune diseases?
Organ-specific autoimmune diseases affect particular targets in the body, whereas systemic diseases engage multiple organs. Both types of autoimmune diseases may coexist in the same patient, either sequentially or concurrently, sustained by the presence of autoantibodies directed against the corresponding autoantigens.
What are some examples of systemic autoimmune diseases?
Systemic autoimmune diseases are a group of common diseases, including rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathy, Sjogren’s syndrome, polymyositis, and dermatomyositis, etc. They are one of the leading causes of death and disability.
Does having Sjogren’s make you immunocompromised?
As a note – not all Sjögren’s patients have compromised immune systems. This specific risk factor is for those who regularly take drugs to suppress the immune system.
Which of the following is not organ specific autoimmune disease?
Chapter 18, Question 1. 1 Which of the following is a non-organ-specific (systemic) autoimmune disease: A Myasthenia gravis.
Which is an example of an organ specific autoimmune disease?
Organ-specific autoimmune diseases are those where a particular organ or tissue is preferentially targeted by the patient’s immune system. For example, the thyroid gland in patients with Graves disease, the beta cells of the endocrine pancreas in patients with type 1 diabetes, or the skin in patients with vitiligo.
What is the normal consequence of autoimmune disease?
Autoimmune disease occurs when a specific adaptive immune response is mounted against self antigens. The normal consequence of an adaptive immune response against a foreign antigen is the clearance of the antigen from the body.
Why are autoimmune responses a natural consequence of the open repertoire?
Autoimmune responses are a natural consequence of the open repertoires of both B-cell and T-cell receptors, which allow them to recognize any pathogen.
Are there any autoimmune responses to self tissues?
But although self-tolerance is the general rule, sustained immune responses to self tissues occur in some individuals, and these autoimmune responses cause the severe tissue damage that Ehrlich predicted.