What are the classification of antineoplastic agents?
The antineoplastic agents are not easily classified. Historically, they are categorized as (1) alkylating agents, (2) antimetabolites, (3) natural products, (4) hormones and antagonists, and (5) miscellaneous. In recent years, however, the miscellaneous group has come to include some of the most important agents.
What are the classes of anticancer drugs?
There are several major classes of anticancer drugs; these include alkylating agents, antimetabolites, natural products, and hormones. In addition, there are a number of drugs that do not fall within those classes but that demonstrate anticancer activity and thus are used in the treatment of malignant disease.
Which antineoplastic drugs are classified as alkylating agents?
Examples
- Cyclophosphamide — the most widely used alkylating agent of modern times.
- Chlormethine also known as mechlorethamine or mustine (HN2) — the first alkylating agent to receive regulatory approval.
- Uramustine or uracil mustard.
- Melphalan.
- Chlorambucil.
- Ifosfamide.
- Bendamustine.
What are anticancer agents Slideshare?
Anticancer Drug, also called Anti-Neoplastic drug, that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include Alkylating Agents, Anti-metabolites, Plant Alkaloids and Hormones.
What are Antineoplastics drugs?
Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.
What are the classical alkylating agents?
Alkylating agents in the classic family include nitrogen mustard, cyclophosphamide, chlorambucil, melphalan, busulfan, and ifosfamide.
What are DNA alkylating agents?
Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from linking as they should. This causes breakage of the DNA strands, affecting the ability of the cancer cell to multiply.
What are the 6 classes of chemotherapy drugs?
Some of the well known classes of cancer chemotherapy agents include alkylating agents, plant alkaloids, antimetabolites, anthracyclines, topoisomerase inhibitors and corticosteroids.
- Normal cell cycle.
- Alkylating agents.
- Antimetabolites.
- Anthracyclines.
- Topoisomerase inhibitors.
- Plant alkaloids.
- Corticosteroids.
Which is the best description of an antineoplastic agent?
1. ANTINEOPLASTIC AGENTSPresenter: Robin Gulati 2. Contents• Classification of antineoplastic agents• Mechanism of action• Resistance to antineoplastic agents• Some treatment protocols 3. Classification of Antineoplastic agentsI. Cytotoxic drugs (directly act on cells) a) Alkylating agents i. Nitrogen mustards ii. Ethyleneimine iii.
When to use horizontal cabinets for antineoplastic agents?
EXPOSURE TO ANTINEOPLASTIC AGENTS IN THE PHARMACY LABORATORY SETTING AND ONGOING NIOSH STUDIES – Class 1 (human carcinogen) 9 plus 2 combinational therapies Horizontal cabinets should not be used for hazardous drug preparation | PowerPoint PPT presentation | free to view
How are antineoplastic drugs affect nucleic acid synthesis?
Drug Affecting Nucleic Acid Synthesis Hydroxyurea Drug Destroying DNA Structure & its Function Antitumor Antibiotics Cisplatin & carboplantin Alkylating Agent Camptothecins 13.
What are the causes of resistance to anticancer drugs?
RESISTANCE TO ANTICANCER DRUGS• Decreased accumulation of cytotoxic drugs in cells as a result of the increased expression of cell surface, energy- dependent drug transport proteins.• A decrease in the amount of drug taken up by the cell (e.g. in the case of methotrexate).•
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