What does warfarin cause in pregnancy?
Warfarin crosses the placenta during pregnancy and has the potential to cause teratogenesis and bleeding in the fetus. Warfarin and other coumarin derivatives cause an embryopathy commonly termed fetal warfarin syndrome (FWS).
When does warfarin make teratogenic?
Warfarin is a teratogenic drug. The increased risk of birth defects occurs particularly with warfarin use during ~6-9 weeks gestation.
Is warfarin a teratogen?
Warfarin is known to be teratogenic, producing characteristic abnormalities, namely a hypoplastic nose, stippled epiphyses, and skeletal abnormalities.
Is Coumadin a teratogen?
Coumadin, teratogenicity of: The anticoagulant (“blood- thinner”) Coumadin is a known teratogen, an agent that can disturb the development of the embryo and fetus and lead to birth defects..
What is the antidote of warfarin?
Vitamin K1 is the only effective antidote for long-term management, but it takes several hours to reverse anticoagulation. Oral vitamin K 1 has excellent bioavailability, is rapidly absorbed, and is recommended in the absence of serious or life-threatening hemorrhage.
How does warfarin cause teratogenicity?
Warfarin is a teratogen which can cross from the mother to the developing fetus. The inhibition of clotting factors can lead to internal bleeding of the fetus while the inhibition of osteocalcin causes lower bone growth. As well as birth defects, warfarin can induce spontaneous abortion or stillbirth.
Can I get pregnant while on warfarin?
Thompson on can i get pregnant or have surgery while taking warfarin: Warfarin is known to cause birth defects (fetal warfarin syndrome) if used in the first trimester, and neurological defects if used in the second and third trimesters It is important to avoid getting pregnant while on warfarin.
How does warfarin eliminated from the body?
Excretion: Warfarin is primarily eliminated as metabolites by glomerular filtration in the kidney (92% via urine).
What are the contraindications of warfarin?
- Uncontrolled bleeding;
- Open wounds;
- Active ulcer disease;
- Recent brain, eye, or spinal cord injury or surgery;
- Severe liver or kidney disease;
- Uncontrolled hypertension;
- OB: Crosses placenta and may cause fatal hemorrhage in the fetus. May also cause congenital malformation.
What are the symptoms of fetal warfarin syndrome?
Jump to navigation Jump to search. Fetal warfarin syndrome is a disorder of the embryo which occurs in a child whose mother took the medication warfarin (brand name: Coumadin) during pregnancy. Resulting abnormalities include low birth weight, slower growth, mental retardation, malformed bones, cartilage and joints, deafness and small head size.
When to seek medical attention for warfarin side effects?
Warfarin side effects that require immediate medical attention. Rarely, warfarin can cause the death of skin tissue (necrosis). This complication occurs most often three to eight days after you start taking warfarin. If you notice any sores, changes in skin color or temperature, or severe pain on your skin, seek immediate medical care.
How does warfarin syndrome affect the central nervous system?
Defects of the central nervous system can lead to profound mental challenges. Fetal warfarin syndrome can lead to microcephaly; an abnormally small head, hydrocephaly; increased ventricle size and CSF volume, and agenesis of the corpus callosum.
Are there any drugs that interact with warfarin?
An interaction might lower the effectiveness of warfarin or increase your risk of bleeding. Common drugs that can interact with warfarin include: Acetaminophen (Tylenol, others) or acetaminophen-containing products Antifungal medications, such as fluconazole (Diflucan)