What is CD66 a marker for?
CD66c is a novel marker for colorectal cancer stem cell isolation, and its silencing halts tumor growth in vivo. Cancer. 2013 Feb 15;119(4):729-38. doi: 10.1002/cncr.
What is CD66?
CD66, a member of the carcinoembryonic antigen family, is known to be expressed on cells of myeloid and monocytic origin and has also been demonstrated on blasts from patients with B-lineage acute lymphoblastic leukaemia.
What is the most important role of neutrophils?
Neutrophils are important effector cells in the innate arm of the immune system (Mayadas et al., 2014). They constantly patrol the organism for signs of microbial infections, and when found, these cells quickly respond to trap and kill the invading pathogens.
What happens during inflammatory response?
The inflammatory response (inflammation) occurs when tissues are injured by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals including histamine, bradykinin, and prostaglandins. These chemicals cause blood vessels to leak fluid into the tissues, causing swelling.
Where are CD66 glycoproteins found in the body?
The CD66 molecules are 180-200 kDa glycoproteins of carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells.
How does CD66 increase expression in granulocytes?
The expression of CD66 increases significantly on granulocytes upon their activation. CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the
What is the role of CD66 in cell adhesion?
CD66 is involved in cell adhesion and growth, neutrophil activation, and signaling. Finally, studies have shown that the CD66 variants interact with each other homo- and heterotypically. Applications Reported: This CD66a-B1.1 antibody has been reported for use in flow cytometric analysis.
What is the role of CD66 in neutrophil effector function?
CD66: role in the regulation of neutrophil effector function. Abstract. Neutrophils express several heavily glycosylated carcinoembryonic antigen (CEA)‐related glycoproteins (CD66 antigens) which have been implicated in adhesion to E‐selectin and as receptors for the lectins galectin 3 and bacterial type‐1 fimbriae.