What is EDS V?
A rare systemic disease characterized by a severe phenotype in all male patients, combining abnormality of connective tissue typical for Ehlers-Danlos syndrome (including joint hypermobility, scoliosis, soft and doughy skin, hyperextensible skin, abnormal scarring, facial peculiarities, and generalized hypotonia, among …
What does type V collagen do?
Type V collagen is a fibrillar collagen. It is essential for fibrillation of types I and III collagen, and consequently for optimal fibrillary formation and tissue quality. Type V collagen contributes to the bone matrix, corneal stroma, and the interstitial matrix of muscles, liver, lungs, and placenta.
What is the most severe form of Ehlers-Danlos syndrome?
A more severe form of the disorder, called vascular Ehlers-Danlos syndrome, can cause the walls of your blood vessels, intestines or uterus to rupture.
What is Ehlers-Danlos type 7?
The arthrochalasia type EDS (formerly type VIIa and VIIb) is characterized by severe generalized joint hypermobility with multiple dislocations including congenital bilateral dislocation of the hips, muscular hypotonia and distinct dysmorphic features.
Where is type V collagen found?
Type V collagen is a form of fibrillar collagen associated with classical Ehlers-Danlos syndrome. It is found within the dermal/epidermal junction, placental tissues, as well as in association with tissues containing type I collagen. Autoimmunity against type V collagen is associated with lung transplant failure.
Is EDS progressive?
EDS is a slowly progressive disease. EDS symptoms vary by type and range from mildly loose joints to life-threatening complications. There are 13 defined types of EDS. Apart from these 13 types, there are several other types identified as EDS.
How painful is Ehlers-Danlos syndrome?
Ehlers-Danlos syndrome tends to result in chronic pain and discomfort, often in the joints, muscles, or nerves. It can also cause stomach problems and headaches. Medication can be a crucial part of a pain management strategy for many people with Ehlers-Danlos syndrome.
What is the life expectancy of someone with Ehlers Danlos?
Patients with the classical and hypermobility forms of Ehlers-Danlos syndrome have a normal life expectancy. About 80% of patients with vascular Ehlers-Danlos syndrome will experience a major health event by age 40 and the life expectancy is shortened, with an average age of death of 48 years .
What are the best exercises for Ehlers Danlos syndrome?
Many patients with EDS can benefit from low-impact exercises such as Pilates and Tai Chi, which help build core strength. Yoga can also be beneficial but poses must be done carefully as there is the risk of overextending joints in some positions.
Is Ehlers Danlos an autoimmune disease?
A much rarer group of connective tissue disorders is called Ehlers-Danlos syndrome. Unlike the diseases noted above, Ehlers-Danlos syndrome is not an autoimmune condition, it’s an inherited disorder.
What does Ehlers Danlos Syndrome look like?
People who have Ehlers-Danlos syndrome, vascular type, often share distinctive facial features of a thin nose, thin upper lip, small earlobes and prominent eyes. They also have thin, translucent skin that bruises very easily.