What is the extracellular matrix composed of in cartilage?
type II collagen
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS).
Which component of the extracellular matrix gives cartilage its tensile strength?
The collagen matrix gives cartilage its form and tensile strength. Proteoglycans and non-collagenous proteins bind to the collagenous network and help to stabilize the matrix framework and bind the chondrocytes to the macromolecules of the network.
Is cartilage part of the extracellular matrix?
Cartilage is composed of specialized cells called chondrocytes that produce a large amount of collagenous extracellular matrix, abundant ground substance that is rich in proteoglycan and elastin fibers. Cartilage does not contain blood vessels (it is avascular) or nerves (it is aneural).
How does the extracellular matrix and its components differ in bone and cartilage?
They are both made up of cells embedded in an extracellular matrix. It is the nature of the matrix that defines the properties of these connective tissues. Cartilage is thin, avascular, flexible and resistant to compressive forces. Bone is highly vascularised, and its calcified matrix makes it very strong.
What are the two main components of the extracellular matrix?
Two main classes of extracellular macromolecules make up the matrix: (1) polysaccharide chains of the class called glycosaminoglycans (GAGs), which are usually found covalently linked to protein in the form of proteoglycans, and (2) fibrous proteins, including collagen, elastin, fibronectin, and laminin, which have …
What are the main components of extracellular matrix?
Extracellular matrix (ECM) is an extensive molecule network composed of three major components: protein, glycosaminoglycan, and glycoconjugate.
What is an example of extracellular matrix?
The extracellular matrix is the non-cellular portion of a tissue. In animal tissues, the main components of the extracellular matrix are the fibrous elements (e.g. collagen, elastin, reticulin), link proteins (e.g. fibronectin, laminin), and space filling molecules (e.g. glycosaminoglycans). …
What makes up the cartilage and bone extracellular matrix?
Cartilage and bone extracellular matrix The extracellular matrix (ECM) is a complex of self assembled macromolecules. It is composed predominantly of collagens, non-collagenous glycoproteins, hyaluronan and proteoglycans.
What are the components of the cartilage ECM?
Cartilage ECM is composed mainly of two components defining its mechano-physical properties: the collagenous network, responsible for the tensile strength of the cartilage matrix, and the proteoglycans (mainly aggrecan), responsible for the osmotic swelling and the elastic properties of the cartilage tissue.
What happens to the extracellular matrix in osteoarthritis?
In osteoarthritis, a deregulated balance between proteinases degrading (protein enzymes in the inflammatory process breaks down) the extracellular matrix and their inhibitors (which should stop the process) may be responsible for cartilage degeneration.”
Is the extracellular matrix a part of healing?
There are many studies which suggest that patients heal better when they understand how they are healing. One of the most fascinating parts of our bodies’ healing components is the extracellular matrix (ECM).